综合护理干预对小儿高热惊厥家属心理状态的影响分析

目的小儿高热惊厥应用综合护理干预措施对家属心理状态的影响。方法选择郑州大学附属儿童医院2016年4月—2017年6月收治的100例小儿高热惊厥患者为研究对象,按照随机数字表法将其分为观察组、对照组,并对比分析患儿基础病情、SAS和SDS评分。结果观察组患儿在护理后退热时间为(26.8±6.4)h、惊厥消失时间为(4.3±0.8) h和住院时间为(6.2±1.2) d均短于对照组患儿(P0.05)。两组患儿在护理后的SAS、SDS评分均优于护理前,且观察组患儿的SAS为(33.10±6.92)分、SDS为(38.23±5.55)分均优于对照组(P0.05)。结论小儿高热惊厥应用综合护理干预措施具有显著的护理效果,能够缩短惊厥消失时间、住院时间与退热时间,同时还可以缓解患儿家属的焦虑与抑郁,改善心理状态,有助于患儿早日恢复。     

Health-related lifestyles and obesity among adults with and without disability in Australia: Implication for mental health care

Background

Numerous studies have reported people with disabilities are more likely to be obese and engaged in unhealthy lifestyles. Few studies explored the mechanism of health-related lifestyles and obesity among people with disabilities.

Impact of sampling rate on statistical significance for single subject fMRI connectivity analysis

A typical time series in functional magnetic resonance imaging (fMRI) exhibits autocorrelation, that is, the samples of the time series are dependent. In addition, temporal filtering, one of the crucial steps in preprocessing of functional magnetic resonance images, induces its own autocorrelation. While performing connectivity analysis in fMRI, the impact of the autocorrelation is largely ignored. Recently, autocorrelation has been addressed by variance correction approaches, which are sensitive to the sampling rate. In this article, we aim to investigate the impact of the sampling rate on the variance correction approaches. Toward this end, we first derived a generalized expression for the variance of the sample Pearson correlation coefficient (SPCC) in terms of the sampling rate and the filter cutoff frequency, in addition to the autocorrelation and cross‐covariance functions of the time series. Through simulations, we illustrated the importance of the variance correction for a fixed sampling rate. Using the real resting state fMRI data sets, we demonstrated that the data sets with higher sampling rates were more prone to false positives, in agreement with the existing empirical reports. We further demonstrated with single subject results that for the data sets with higher sampling rates, the variance correction strategy restored the integrity of true connectivity.     

唤醒状态联合中央沟定位切除脑运动区胶质瘤对患者运动功能保护作用探讨

目的 探究唤醒状态联合中央沟定位对脑运动区胶质瘤切除术患者运动功能的保护作用。方法 选取本院2016年12月—2017年10月期间收治的脑运动区胶质瘤患者70例。所有患者均行唤醒状态联合中央沟定位运动区胶质瘤切除术。观察患者术后复发情况及术后第6、12个月的Kamofsky评分,并记录并发症发生情况。结果 所有患者均成功完成手术,未出现术中大出血、死亡等严重并发症。70例患者中,有40例全切除,26例次全切除,4例大部分切除。术后,感觉减退者有6例,肌力下降者有5例,肌力下降伴感觉减退者有2例,并发症发生率为18.57%(13/70)。6个月后,应用增强MRI显示有4例患者肿瘤灶周围明显强化,进一步使用正电子发射断层显像发现有1例患者肿瘤复发。术前及术后第6、12个月的Kamofsky评分分别为(89.62±11.88)及(80.73±9.91)、(65.82±12.36)。结论 唤醒状态联合中央沟定位能最大限度切除脑运动区胶质瘤,提高患者预后效果。     

认知行为干预在冠心病患者护理中的应用效果

目的观察认知行为干预在冠心病患者护理中的应用效果。方法选取本院2016年12月～2018年2月期间收治的53例冠心病患者,根据住院号奇偶性情况将其随机分为观察组(n=27)和对照组(n=26),对照组予以常规护理,观察组予以认知行为干预。比较两组患者控制态度评分、心理状况评分、生活质量改善情况及依从性。结果观察组控制态度评分、心理状况评分、生活质量改善情况及依从性与对照组比较,差异有统计学意义(P0.05)。结论在冠心病患者护理中给予认知行为干预应用效果极佳,可作为临床干预首选措施。     

PROMs in post-mastectomy care: Patient self-reports (BREAST-Q™) as a powerful instrument to personalize medical services

One of the goals of immediate breast reconstruction (IBR) is to satisfy the patient's outcome. Recent studies therefore tended to focus on the patient's perception of the care and on the impact on quality of life using patients-reported-outcome-measures (PROMs), able to measure the health status directly without the clinician's interposition.We present a preliminary prospective study on 333 patients who underwent mastectomy with IBR in a two-year period, in a single Italian centre, using a dedicated PROMs, the BREAST-Q™, to determine the patient's satisfaction.We studied two groups of IBR: Group A (two-step with tissue-expander) and Group B (one-step: prosthesis/mesh) and conducted a pre- and post-operative comparison for each group to evaluate score-gain over time, and a group-score comparison to determine whether differences were significant between reconstruction types.Two-hundred-and-nine were actually enrolled and 132 completed all the questionnaires. The response rate was 62.8% and the compliance rate (completion of all the questionnaires) was 63.1%. In both groups all the analyzed domains worsened comparing the pre and post-operative period; the differences were statistically significant only for physical and sexual-wellbeing. In the comparison between the two groups, none of the detected differences reached the statistical significance.According to our experience, we can state that PROMs could improve the health concept redefining the variables to be monitored even if data is still insufficient to draw any definitive conclusion. PROMs can help surgeons and patients decide the most appropriate surgery for a particular patient-profile and to identify those who require further support.     

Design,synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy

Angiokinases, such as vascular endothelial-, fibroblast- and platelet-derived growth factor receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti-angiogenesis therapy using multi-angiokinase inhibitor has achieved great success in recent years. In this study, we presented the design, synthesis, target identification, molecular mechanism, pharmacodynamics (PD) and pharmacokinetics (PK) research of a novel triple-angiokinase inhibitor WXFL-152. WXFL-152, identified from a series of 4-oxyquinoline derivatives based on a structure–activity relationship study, inhibited the proliferation of vascular endothelial cells (ECs) and pericytes by blocking the angiokinase signals VEGF/VEGFR2, FGF/FGFRs and PDGF/PDGFRβ simultaneously in vitro. Significant anticancer effects of WXFL-152 were confirmed in multiple preclinical tumor xenograft models, including a patient-derived tumor xenograft (PDX) model. Pharmacokinetic studies of WXFL-152 demonstrated high favourable bioavailability with single-dose and continuous multi-dose by oral administration in rats and beagles. In conclusion, WXFL-152, which is currently in phase Ib clinical trials, is a novel and effective triple-angiokinase inhibitor with clear PD and PK in tumor therapy.     

手术室心理护理对手术患者精神状态的影响

目的探讨手术室心理护理对手术患者焦虑、抑郁状态及护理满意度的影响。方法以医院2017年1月—2019年4月在医院接受手术治疗的1200例患者展开研究,随机将其划分为研究组(n=600)与对照组(n=600),分别接受常规基础上的心理护理以及单纯常规护理,对比分析患者抑郁、焦虑评分、护理满意度。结果治疗后,与对照组比,观察组抑郁、焦虑评分均更低;且研究组(97.0%)患者护理满意度高于对照组(83.7%),差异有统计学意义(P<0.05)。结论心理护理干预对于手术患者精神干预结果比较好,不仅可以改善患者的抑郁、焦虑情况,也能提升其护理满意度。     

Percepciones de las enfermeras sobre el apoyo de los compañeros de trabajo en el lugar de trabajo: investigación cualitativa

ObjectiveAlthough the psychological factors of the work environment affect the quality of employees’ performance more than physical factors, they have not been broadly explained yet. This study is conducted to explore nurses’ perceptions of the co-worker support as psychological resource in the workplace.MethodThe present study is a qualitative research. Fourteen staff nurses who were working in hospitals affiliated to the Khoy University of Medical Sciences, Iran were selected based on purposeful sampling and interviewed using un-structured in-depth interviews. All interviews were recorded, transcribed, and analyzed using conventional content analysis approach through constant comparative method.ResultsData analysis revealed four major themes with 11 sub themes. The four major themes include ‘emotional support’, ‘effective working relationship and collaboration’, ‘suitable social relationships’, and ‘guidance and teaching’.ConclusionThe results showed that, nurses had a positive perception of their colleagues’ support in the workplace. Co-worker support is a multidimensional phenomenon and is influenced by various factors. Perceiving support from the colleague and having a sense of support can promote the quality of care and increase dealing with stressful situations in nursing. Therefore, communication and flexibility skills should be taught to both staff and managers in this regard.     

Resilience Among Professional Health Workers in Emergency Services

IntroductionAlthough it seems logical that working in an emergency service implies having a great capacity to face extreme situations, resilience in health care workers has been shown to be related not only to individual personality characteristics but also with external factors. The objective of this study was to understand the resilience of health professionals working in hospital and in-hospital emergency services and to determine the relationships of resilience with sociodemographic and work-related conditions.MethodsThis cross-sectional study included emergency physicians, nurses, and nursing assistants. Sociodemographic variables, work characteristics, and the Resilience Scale–25 were analyzed. Data were not missing at random and models with imputed data were tested.ResultsA total of 321 professionals participated. Their mean age was 43.36 years (SD 8.73), and 81.31% were women. The mean resilience score was 133.38 (SD 17.11), which corresponds to moderately low to moderate levels. Being single (B = −7.35; P < .01) or divorced (B = −8.26; P = .04) were associated with decreased resilience in the raw score of the Resilience Scale-25. Working shifts that do not include night shift (OR = 2.00, 95% CI 1.04, 3.90, P = .04) and being a nurse (OR = 2.11, 95% CI 1.07, 4.18; P = .03) were associated with higher odds of belonging to categories of lower resilience levels. However, more professional work experience was related to lower odds of belonging to categories of lower resilience levels (OR = 0.94, 95% CI 0.89-0.99, P < .04). Several variables, including marital status, demonstrated inconsistent associations across different modeling methods.ConclusionsResilience in professional health workers was related to personal and working conditions. The scores of emergency staff were low and improvement with specific strategies is needed.